"Does Ruconest expire?"

"Yes. Ruconest has a labeled shelf life of 48 months. Do not use medication past its expiration date."

How Long Does Ruconest Last?

Q: "How long does Ruconest last?"

"Ruconest has a shelf life of 48 months according to federal drug label data. Always check the expiration date on your specific packaging."

Generic: C1 ESTERASE INHIBITOR RECOMBINANT

Source: Federal Drug Label Data

48 months

Shelf life from federal drug label data

Storage Conditions

Room temperature Do not freeze Protect from light

Reported Side Effects

From 5,764 FDA adverse event reports (FAERS). 32.8% classified as serious.

5,764

Total Reports

32.8%

Serious

Side Effects Tracked

Side Effect	Reports
HEREDITARY ANGIOEDEMA	949
INTENTIONAL PRODUCT USE ISSUE	715
DRUG INEFFECTIVE FOR UNAPPROVED INDICATION	510
DRUG INEFFECTIVE	410
CONDITION AGGRAVATED	384
PRODUCT USE IN UNAPPROVED INDICATION	380
PHARYNGEAL SWELLING	359
WEIGHT DECREASED	228
PRODUCT DOSE OMISSION ISSUE	214
WEIGHT INCREASED	214
VASCULAR ACCESS SITE COMPLICATION	168
WEIGHT FLUCTUATION	153
UNDERDOSE	150
COVID-19	148
MATERNAL EXPOSURE DURING PREGNANCY	146

Data from FDA Adverse Event Reporting System (FAERS). Reports reflect consumer/provider submissions — higher counts may reflect higher usage, not necessarily higher risk. Not all reports establish a causal link.

Manufacturer

Pharming Healthcare Inc.

Storage Information

16 HOW SUPPLIED/STORAGE AND HANDLING 16.1 How Supplied RUCONEST is supplied in single-use 25 mL glass vials with a stopper (siliconized chlorobutyl rubber) and a flip-off seal (aluminum and colored plastic). Each carton contains one single-use vial. Each vial contains 2100 U rhC1INH lyophilized powder for reconstitution for injection. 16.2 Storage and Handling Store in the original package in order to protect from light. Shelf life: 48 months when stored at 36ºF - 77ºF (2ºC - 25ºC). Do not freeze. Each vial of RUCONEST should be reconstituted with 14 mL Water for Injection (not supplied). The reconstituted solution contains 150 U/mL rhC1INH and is clear and colorless. Each vial of RUCONEST is for single use only. RUCONEST contains no preservative. Any product that has been reconstituted should be used immediately, or within 8 hours stored at 36ºF - 46ºF (2ºC - 8ºC). Discard partially used vials after treatment. 11 DESCRIPTION RUCONEST is a recombinant analogue of human complement component 1 esterase inhibitor for intravenous injection. RUCONEST is purified from the milk of transgenic rabbits, and supplied as a sterile, preservative-free, white/off-white lyophilized powder for reconstitution for injection. One U of rhC1INH activity is defined as the equivalent of C1 esterase inhibiting activity present in 1 mL of pooled normal plasma. RUCONEST is a soluble, single-chain glycoprotein containing 478 amino acids, with a molecular mass of 68 kDa, of which approximately 22% compri

Medication Rankings

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Important: This information is from federal drug label data and is for reference only. Always follow the specific expiration date printed on your medication packaging. Consult your pharmacist or healthcare provider with questions about medication storage or expiration.

Data source: View Ruconest on DailyMed (NIH) | Federal drug label data.

Page generated: 2026-03-29